When doctors won't tell . . . Of all the online nutritional information, nutritional facts, medical and dietary sites there are to choose from, in an article entitled "How to ease the pain" The Sunday Times magazine, Culture, published a list of just five websites it considered reliable and informative.
This site was one of that five.
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Barry Groves, PhD
Exposing dietary misinformation
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Insulin resistance is the greatest risk factor for heart attacks
We're all told that to avoid a heart attack we must reduce our LDL cholesterol. However, it might be better to stop eating a 'healthy' diet.
Just published in the February 2009 edition of Diabetes Care is a 60-year study which shows that the most important factor increasing the risk of a heart attack is not cholesterol after all, it is insulin resistance — and insulin resistance is caused by eating a 'healthy' carbohydrate-based diet, particularly if that diet also includes 'healthy' vegetable margarines and cooking oils.
The abstract of this study is below. The full paper can be downloaded here.
Eddy D, Schlessinger L, Kahn R, et al. Relationship of Insulin Resistance and Related Metabolic Variables to Coronary Artery Disease: A Mathematical Analysis. Diabetes Care 2009; 32 : 361-366
Abstract
OBJECTIVE — People with diabetes have an increased risk of coronary artery disease (CAD). An unanswered question is what portion of CAD can be attributed to insulin resistance, related metabolic variables, and other known CAD risk factors.
RESEARCH DESIGN AND METHODS — The Archimedes model was used to estimate the proportion of myocardial infarctions that would be prevented by maintaining insulin resistance and other risk factors at healthy levels. Person-specific data from the National Health and Nutrition Examination Survey 1998–2004 were used to create a simulated population representative of young adults in the U.S. This population was then entered into a series of simulated clinical trials designed to explore the effects of each risk factor. Each trial had a control arm (all risk factors were allowed to progress without interventions) and a treatment arm (a risk factor was held to its value in young healthy adults). The trials continued for 60 years. The effects of these hypothetical "cures" of each risk factor provide estimates of their impact on CAD.
RESULTS — In young adults, preventing insulin resistance would prevent ~42% of myocardial infarctions. The next most important determinant of CAD is systolic hypertension, prevention of which would reduce myocardial infarctions by ~36%. Following systolic blood pressure, the most important determinants are HDL cholesterol (31%), BMI (21%), LDL cholesterol (16%), triglycerides (10%), fasting plasma glucose and smoking (both ~9%), and family history (4%).
CONCLUSIONS — Insulin resistance is likely the most important single cause of CAD. A better understanding of its pathogenesis and how it might be prevented or cured could have a profound effect on CAD.
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Last updated 20 February 2009
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