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Vegetarians More Likely To suffer from Glycation
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Katarína Sebeková, Marica Krajcovicová-Kudlácková, Reinhard Schinzel, et al. Plasma levels of advanced glycation end products in healthy, long-term vegetarians and subjects on a western mixed diet. Eur J Nutr 2001; 40 : 275-281.
Summary
Background Evidence indicates that food-derived Maillard's reaction products are absorbed and yet can be detected in the circulation.
Aim of the study We postulated that consumption of the heat-treated food by omnivores could be reflected by higher plasma levels of advanced glycation end products (AGEs) in comparison with vegetarians,who in cooking (by keeping away from meat) use lower temperatures and less time for heating.
Methods Plasma fluorescent AGEs (350/450 nm) and Nĺ- (carboxymethyl)lysine (CML, competitive ELISA) levels were investigated in 3 groups of healthy vegetarians (9 vegans-V, 19 lactoovo-vegetarians — VLO and 14 semi-vegetarians — VS) and compared with those of age-matched omnivores (O, n=19). Mean duration of vegetarian diet was V: 7.2±1.0,VLO: 8.2±0.8 and VS: 7.9±1.1 years.
Results Both fluorescent AGE (O: 9.9±0.5;V: 10.8±0.7, LO: 13.1±0.8* and SV: 11.6±1.2 x103 AU), and CML levels (O: 427.1±15.0,V: 514.8±24.6*, LO: 525.7±29.5**, SV: 492.6±18.0* ng/ml) were significantly lower in omnivores than in vegetarians. Plasma glucose, parameters of renal function (plasma concentration of creatinine and cystatin C, calculated glomerular filtration rate — GFR) as well as C-reactive protein levels were within the normal range and did not differ significantly between the groups. Thus, neither decline of kidney
function nor inflammatory processes contributed to the rise in plasma AGEs.
Conclusion Enhanced plasma AGE levels in vegetarians in comparison to omnivores are herein presented for the first time. Mechanisms of AGE elevation and potential pathophysiological relevance of this finding are to be elucidated in prospective studies.
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COMMENT: AGEs are not healthy. It is this glycation that contributes to the complications of diabetes; glycation has also been shown to worsen heart disease risk. Indeed, glycation is caused by the high blood glucose levels seen in diabetics. This study suggests that becoming a vegetarian may not be a good idea, particularly if you are overweight or have any other condition that suggests insulin resistance and a likelihood of diabetes.
Last updated 19 March 2005
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